1. Biggest Hands

Mark's hands are 20 times bigger than a normal adult male's. After learning that his condition may require amputation, Mark stopped seeing doctors.

2. "Ugliest" Man

Godfrey has a rare disorder that has left him disfigured. With his condition worsening, he is seeking medical answers that will determine his future.

3. Upside Down with a Twist

In Brazil, Claudio lives with a condition that bent his head backward. In Norway, Birgitte lives with a different presentation of the same condition.

4. Peaks and Valleys

In Turkey, the world's tallest woman lives with an unknown genetic condition, while in Brazil, the world's shortest couple navigate dwarfism.

5. Face to Face

Milagros lives with tumors so heavy that her face droops to her torso. Lizzie prepares to live independently even after tumors grow over her eyes.

6. Hair Today, Gone Tomorrow?

In rural Indian, Lalit's face and body have been thickly covered in hair since the day he was born.

7. Skin In The Game

Mahfuza and Nelly are living with Harlequin ichthyosis, one of the world's rarest and most severe skin conditions.

8. Keep Calm and Girdle On

Summer has macromastia, a condition that causes her breasts to keep growing, so she travels from Scotland to Los Angeles looking for a solution.

9. On My Side

Conjoined twins Jose Luis and Jose Armando get advanced medical care. Conjoined twins Pin and Pan navigate their ongoing differences.

10. Bending the Rules

Dimas' family worries his martial arts training will harm his oddly bendy body. Herson's backward-bending knees are failing.